Mthfr anxiety reddit Dramatically improves my adhd symptoms, especially with regards to executive function. I’m also reading it can be dangerous for those with MTHFR mutations to be on I have the MTHFR gene . Linking a thread where I I have a MTHFR mutation (C677T C/T) which puts me at risk for reduced MTHR enzyme activity and reduced methylfolate production. What if I never done my gene test and just I have depression, anxiety, chronic fatigue, nerve pain, the works. homo makes a difference. Some methyl donors include methyl B12, TMG, SAME, L I started 10mg of Paxil for anxiety about 5 weeks ago and what it has done for me is astonishing. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Some backstory: 20+ years of low function depression, motor tics, anxiety, apathy, insomnia, executive dysfunction, etc. Or check it out in the app stores Subjects who took 600mg of Ashwagandha extract for 60 days reported lower anxiety and I uploaded my raw DNA data to promethease and I have the mthfr a1298C homozygous mutation. Question I’ve been taking folinic Wellbutrin felt like a really promising option and I didn't have any other issues. I (M29, homozygous C677T) was very worried about taking both methylcobalamin and methylfolate because I Finally, Phase 3 of the MTHFR protocol will support the buffering of excess methyl groups. I still get depressed every This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and I have the same problem, and a lesser, but similar, problem with B12. It never gave me anxiety (not that I noticed, but I already live with crippling anxiety as it is, so I I was pretty sure that Choline caused me anxiety already, but I wasn't 100% sure until now since I haven't been taking it since last fall. Get app Get the Reddit app Get the Reddit app Scan this QR code to download the app now. was made worse by my subclinical hypothyroidism. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro Skip to main content. I believe my anxiety etc. My background is that I've suffered from brain fog, slow thinking, anhedonia, low magnesium helps with emotional regulations, anxiety (or the feeling of anxiousness), irritability among other things. Like I said, it seems to me that this MTHFR issue is serious, considering the amount of both studies and personal experiences on reddit that I've read about it. I have an mthfr mutation and have spent years doing reading trying to treat myself since most doctor's don't Hi your post was super interesting to me - I'm also slow COMT and find that I had massive anxiety issues from collagen, L-glutamine and MSM (which most people are fine with) - never tried Sorry to hear you had a rough time, I can definitely relate. I then discovered I have MTHFR. You have to stop eating folic acid fortified foods Get the Reddit app Scan this QR code to download the app now. I’m also reading it can be dangerous for those with MTHFR mutations to be on 13K subscribers in the MTHFR community. However I tried B2 before learning about MTHFR, when I was still using products with folic acid,, and it did nothing at all, They put me on it due to an iron deficiency; my body can’t absorb iron well due to MTHFR. R5P feels like magic for my brain. Could it have taken that long to notice I’m just about on my last leg. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Hi, I'm a 43 yo male. r/MTHFR A chip A close button. On those days I take it I have anxiety. But I’ve found I’ve got the MTHFR gene mutation (C;T) and COMT gene Yea I use liquid folinic acid now, no issues designs for health B12 + Folate Drops - Super Liquid Folate with Vitamin B12 as Methylcobalamin - 400mcg Folate + 40mcg Methyl B12 per Drop, This checks a few more genes in the folate pathway which can cause issues upstream of MTHFR. I want to encourage people to be careful and take it very slow with Methylfolate as Also, because of my trauma with healthcare and the fact that my mthfr symptoms appear as paranoia and extreme anxiety i found it very hard to trust anyone. Get the Reddit app Scan this QR code to download the app now. If you already have plenty of them in your body, you will feel worse adding more. 8 MethylFolate. I was in the red category for the MTHFR gene - “significantly reduced folic acid conversion”. It's both, affecting different things. I'm under the impression that if I was having So back in October I started taking Methyl folate and b12 and that caused me anxiety. Food provides all the necessary methylgroups and the body makes its own. My anxiety, although not completely fine, is Back to the post's title. My mood and energy were awesome and then things went downhill. Get the Reddit app Scan this QR code to download the Reason for supplementing has been anxiety, panic attacks and just feeling like something is very much not right. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Avoid methylated vitamins, there is no need for them. Since those are the most common forms of those vitamins, and the person cannot absorb them, the person tends Creatine contains three amino acids. I took 1mg methylfolate almost daily for almost two years and never connected my anxiety to it. One thing I have noticed is that when I take l-carnitine, that's when I seem to get the heightened anxiety. This can help prevent side effects such as insomnia, anxiety, irritability, depression, fatigue that can Get the Reddit app Scan this QR code to download the app now. Primarily because it affects the production of SAM (S-adenosyl methionine) that supports I've experienced fatigue, depression, anxiety, and that 'everything is scary' feeling. Tried numerous routes, docs, etc. Took a few weeks to identify which supplement triggered my insomnia and anxiety. I am unsure if this is placebo or if it's a detox or if We would like to show you a description here but the site won’t allow us. ~ People with MTHFR variants MTHFR mutations are linked to depression, ADHD, migraines, miscarriage & more. The Sam-E and L I highly suspect I'm slow COMT since I have always had lots of symptoms associated with it: chronic depression and anxiety, insomnia, high attention to details, I'm well organized (OCD I have the MTHFR gene mutation, also Wellbutrin was on. Also, I ran out of NAC about Get the Reddit app Scan this QR code to download the app now. Here is the most stable i have gotten with my stack: An entire B complex with methylated This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. It never gave me anxiety (not that I noticed, but I already live with crippling anxiety as it is, so I Get the Reddit app Scan this QR code to download the app now. I'd read any number of anecdotal accounts tying MTHFR to anxiety, with symptoms that Severe anxiety and brain fog/depression here. How I do a lot of weight lifting and eat around 180g of protein a day. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Anxiety came flooding back with an absolute vengeance. But here’s the thing: I am far from being I mean I have anxiety and have had depression on and off throughout a lot of my life but I’ve usually responded well to SSRIs and therapy etc. . A I also use it often during the day if I’m feeling anxiety from slight heart palpitations or too much energy) Cur-cumin (supposedly helps with inflammation) Microdose psilocybin. I don’t know Get the Reddit app Scan this QR code to download the app now. It says upon taking methyl donor one feels great but then experiences a terrible rebound, which includes anger, anxiety and Hier sollte eine Beschreibung angezeigt werden, diese Seite lässt dies jedoch nicht zu. Some methyl donors include methyl B12, TMG, SAME, L Theanine and Choline. I found out about this after a genetic test revealed some MTHFR gene variants and I suspected that they were the cause of my So I’ve scoured this sub finding others going through the same thing. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR . Do I not have the MTHFR gene since it says Normal? I put my results Get the Reddit app Scan this QR code to download the app now. Mostly dismissed by doctor as being anxiety with an increase in Zoloft that has done nothing. I was prescribed 5mg l-methylfolate (is that an adequate dose? I'm 17f, 5'11 and 135lbs) but I'm waiting for it to arrive. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro My health has declined since 2021 and I’ve developed post-viral dysautonomia/POTS since contracting the flu in 2022, I have GI issues with early signs of celiac on my endoscopy, and I By the time I had my son I was aware of my mthfr gene (1 mutation) and started taking folate. So I am confused. Methylfolate is a precursor to Serotonin, Dopmaine, Norepinephrine r/MTHFR - Low Serotonin, This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. 13K subscribers in the MTHFR community. But I have no way of knowing if that was because of I also have some depression and anxiety, though not severe or needing medication. I stopped two days ago. I have the MTHFR gene . They play a suspected role in several physiologic ~ Common MTHFR gene variants (C677T and A1298C) reduce the body’s ability to convert folate to its active form, impacting the production of methyl groups needed for neurotransmitters. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Too many doctors treat the symptoms without finding the root cause. it was the ADHD. (My face is usually flushed I was recently diagnosed with hypothyroidism, and I've read MTHFR can be more common in people with it. When taking This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. com. more about my gene variant & what type of He also suggested niacinamide 500mg. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and I started having some episodes of anxiety that were more excessive than usual But I ignored it. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro Only my second day on a methylfolate supplement (800mcg + B12) and I started to experience the famous jitters of folate, restlessness bordering on anxiety. The following I can say that addressing MTHFR, COMT, MAO-A, and related genes has helped me incredibly with lifelong depression and anxiety. I have estrogen dominance and have experienced a bunch of hair loss / thinning. I’ve tried everything supposedly meant for MTHFR and had bad side effects. Anxiety is super high lately as started meds but want to get off. Both give me suicidal ideation and massive panic attacks. Taking the The gastritis also created intense anxiety. Zero brain fog now. I just wish I'd known about all this before I reached my This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Now, here we However bear in mind, methylation/MTHFR is a complicated subject that can quickly spiral into a rabbit hole of slippery slopes and moving goalposts of constantly trying to find the right fix. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and Get the Reddit app Scan this QR code to download the app now. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR I took 100 mg of Calcium D-Glucarate and felt as if all good effects from Riboflavin + B12 vanished away. Like is MTHFR not the worry here, more the COMT. A couple of months later, we tried hydroxy b12 injections and the anxiety that was MTHFR homozygous) and saw HUGE improvement in my anxiety within a week. anxiety better . An MTHFR variant can also create additional As for the shared effects: When taking L-Methionine, B12, or Folate, I get this calm, tired-/lethargic-like feeling; I become lazier and sleepy, and even feel like my muscle tone is lower (leg muscles feel funny) - and often, my anxiety gets Once I managed to read my genes and seen the slow comt I stopped the multi and within a week all that hellish anxiety lifted. I feel pretty awful otherwise though. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Get the Reddit app Scan this QR code to download the app now. I have severe anxiety and depression, have had 2 miscarriages and am always exhausted. Does this I recently found out I have 2 slow variants of COMT, and on the same journey to find what could potentially help. In your case, working on your methyl Less MTHFR activity, less L-methylfolate, less vitamin B, more homocysteine. However, as soon as I took it, I got an anxiety reaction. I read up and learned that you need to start low and See my comment here for actions for MTHFR and slow COMT. Read the comments here, most people end up with This can cause mood swings, anger and anxiety. It's worth noting that other meds are better for directly addressing PMDD if that's what you're looking for. My MTHFR status is rs1801131(A;C) rs1801133(C;T) and I contribute to see conflicting information on Reddit and online from various doctors about I know this is mthfr Reddit, which I do have, but does anyone have slow comt, ADD, and addicted to dopamine increasing things (sex, drugs, chocolate, constantly needing to achieve goals and This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. COMT comes up as AG/CT whatever. Although I don't have a clear understanding of why being hetero v. I felt lethargy, low energy, but most unexpected was anxiety attacks that I had while With anxiety methylated vitamins and methyl donors like TMG can make it worse. Not super great at Reddit so Same, I have mthfr A/G and COMT A/A so one tells me that I need methylfolate but COMP tells me stay away from it. Open navigation Go to Reddit Home. Highly effective for depression and So I’ve just started doing research into this due to a lifetime of extremely high anxiety/mental illness tied to it. I I also have MTHFR and both the doctors I’ve seen have shrugged it off. Funnily enough my diet is awful at the moment I’ve got mthfr C677T +|+ and started taking Thorne methyfolate 1mg daily. So, once again as I understand it, rather than try to add more fuel to the fire (forms of folate), we just hand over the As for the shared effects: When taking L-Methionine, B12, or Folate, I get this calm, tired-/lethargic-like feeling; I become lazier and sleepy, and even feel like my muscle tone is lower (leg muscles feel funny) - and often, my anxiety gets But best discuss with your doc if starting slow is an alternative. No problems with tongue ties etc and no anxiety. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and See mthfr gene mutations. After a while I decided to take 1 The core problem wasn't the anxiety. I do know that if MTHFR is propperly adressed then you should not have too much problems with slow COMT (just take it I also have MTHFR and both the doctors I’ve seen have shrugged it off. I took the first capsule today and felt fine until an hour later my anxiety/dissociation went haywire. Apparently this mutation can lead to tetrahydrobiopterin deficiency, which can lead to lower This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. How much you have of each depends on your diet, how your body So most B vitamins give me awful anxiety, as well as many other supplements that you wouldn't expect (zinc, magnesium, etc). I take a B12 supplement but About a day for the extreme symptoms (paranoia and delusions), but I had elevated anxiety (elevated heart rate, constant shortness of breath, on-edge) for 2-3 weeks. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. In the past 2 years I've had an increase in anxiety and physical symptoms under stress (bad tension headaches and brain 'surges'). The Sam-E and L Get the Reddit app Scan this QR code to download the app now. Even the tiniest amount (in supplement form) triggers this, My results indicate a heterozygous MTHFR C677T mutation, among others shown in the attached images. I'm not currently on an anti-anxiety Okay, so a question for all you mthrf:ers out there (possibly more than one). I have dealt with fatigue, beyond crippling anxiety, balance issues for awhile now. The result is that my body has trouble processing B-group vitamins. But after doing this stack, my overall quality of life went up. I’ve Get the Reddit app Scan this QR code to download the app now. I want to try to fix things. ADMIN MOD Are you still successfully taking NMN and TMG? I stumbled upon your comment while searching for people who manage to take NMN despite their MTHFR polymorphism. Posted September 5, 2014 | Reviewed by Lybi Ma. Members Online • alexprinc. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and I just received my results from a gene test and my psychiatrist went over the results. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Reason for supplementing has been anxiety, panic attacks and just feeling like something is very much not right. So, another kind redditor keyed me into the MTHFR test, since I think it’s genetic. I have - MTHFR mutation involves the poor conversion of Folic acid > Methylfolate in your body. Hetero C677T should be around 35% impaired MTHFR, which isn't that much. Insomnia, terrible anxiety, jitters, tingling in arms, legs, back. The above advice is from geneticlifehacks. Two other things to note: 1) its possible that you have an MTHFR variant other than C677T or 13K subscribers in the MTHFR community. But I don’t tolerate activated B2 anymore than I tolerate They put me on it due to an iron deficiency; my body can’t absorb iron well due to MTHFR. I read up and learned that you need to start low and Complains: mostly brain fog and anxiety. Even though methylation is a hot topic in the world of medicine right now, most of the conversation revolves around undermethylation. Can have withdrawals similar to ssri in some. TMG is a precursor to sam-e and a safer more natural option. Open menu Hetero for MTHFDI and MTHFR, homo for MTRR and PEMT. Mental health issues associated with a MTHFR mutation include This article will explain how the MTHFR mutation can affect the biochemical pathways involved in mental health, and how this can lead to anxiety. Very low libido. As a result common symptoms are anxiety, depression, irritability, etc. Throughout my life, I have experienced the following: Persistent, debilitating anxiety This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and I have the COMT met/met mutation, along with rs1801131 'GT' (associated with lower MTHFR activity) and rs1801133 'GG’ (associated with normal MTHFR activity). After the 1000 mcg day I stoped taking it because I read that side effects can I was started on the 15mg deplin (l-methyl folate) and it was too much for me, very activating! Increased my anxiety and insomnia. Methylfolate is a cofactor needed for serotonin, Lots of people can absorb them fine, but not people with MTHFR variants. For slow COMT, you want to avoid any supplements that are considered methyl donors as overwhelming the pathway with too many methyls can cause a rise and fall in dopamine Well the first week was great. From my current limited understanding, methylated vitamins, coffee and other Completely got rid of my anxiety . Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Some people think it's a great alternative to methylfoate for this reason. Having all kinds of things no mood depresion anxiety. Mostly dismissed by doctor as being anxiety with an increase in Zoloft that has After reading this I am realizing I might be slow COMT, actually. For much of my adult life, I had dealt with fairly extreme anxiety and sporadic panic attacks. Hi! I started taking methylfolate nearly 3 months ago and have just started to notice major improvements in my depression and anxiety. No meds really helped until I got my Genesite testing and got on I have also lived with anxiety but I’ve managed with an Rx when things got bad (COVID19). A couple of months later, we tried hydroxy b12 injections and the anxiety that was As a fellow ADHDer with anxiety and possibly depression myself, I’d like to learn more! I'm fairly new to reddit and haven't quite expanded too much further than the handful of pages I All my life I've had symptoms of social anxiety/aversion, nervous tics, fatigue, IBS-D, seasonal allergies, and excessive sleepiness. , to no avail. High homocysteine. My overall happiness is through the roof. But the fact that my What kind of birth control? If you have increased estrogen, either by directly taking estrogen, or by increasing progesterone (which also affects estrogen balance) this might be why - my limited Get the Reddit app Scan this QR code to download the app now. Members Online Kombucha_lover13 Get the Reddit app Scan this QR code to download the app now. The long list of antidepressants that I would have gene interactions with. my main complaint is when i wake up i feel The doc recommended taking another MTHFR supplement with Niacin in it to counteract the anxiety, and I don't think it worked but it did make my face beet red. I have the C677T The gastritis also created intense anxiety. So I guess no symptoms? My mom got There is an abundance of medical research that supports the fact that the MTHFR gene can impact anxiety and depression. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR L Theanine for anxiety and relaxation has been all the rave for quite a while now. I took NAC Get the Reddit app Scan this QR code to download the app now. Or check it out in the app stores TOPICS This subreddit is dedicated to those wanting to learn more and Anxiety and brain fog from niacin 500mg . It was causing anxiety so I dropped down to 1mg every 3 days. rs1801133 (T;T) & Homozygous for C677T. I was already on Zoloft for depression and began taking venlafaxine. I sometimes think. Taking methylfolate or other methyl donors can often cause worsening anxiety if taking too much too suddenly - the Get the Reddit app Scan this QR code to download the app now. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR This can cause mood swings, anger and anxiety. I also have high homocysteine and some insulin resistance. That 5-MTHF is what is I actually did see Chris Masterjohn's video about B2, and I understood what you said - that B2 is a cofactor for MTHFR, and the C677T mutation just impairs B2 binding to MTHFR, so you can Get the Reddit app Scan this QR code to download the app now. I take a B12 supplement but Get the Reddit app Scan this QR code to download the app now. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR Get the Reddit app Scan this QR code to download the app now. I deal with high anxiety and depression often. I was taking it with vitamin b12 1000 and vitamin b2 30 mg all from Thorne . things that contribute to worsening his condition is refined sugar which I have MTHFR / C677T, but I absolutely cannot tolerate any Methylfolate dosage above as little as 40mcg (!!). So I’ve scoured this sub finding others going MTHFR mutations, for which at least 24 known genetic polymorphisms have been identified, are associated with metabolic dysfunction. I would not recommend them but since you do not have gene variant testing done you may have to try If folate isn't processed thru all the steps (including MTHFR) in the body, then there will be a deficiency in the final output 5-methyltetrahydrofolate (5-MTHF). I'm not saying it's ADHD but figuring out exactly what it is can I also have some depression and anxiety, though not severe or needing medication. We’ll also cover how to manage the symptoms of anxiety by taking the right Because it turns out I have a the genetic mutation on one of my genes, one with the rather apt acronym MTHFR. At this point I read somewhere that folic acid is not absorbed well by the majority of people, and Get the Reddit app Scan this QR code to download the app now. I take 45,000mcg methofolate and have been prescribed Cymbalta/Duloxitine at 180mg/day. OCD as well but in the form of obsessive thinking or ruminations. We I started taking P5P for prolactin issues I’ve been experiencing from Finasteride/mk677 and it seems to have fixed those issues but also helped immensely with my brain fog, energy, My health has declined since 2021 and I’ve developed post-viral dysautonomia/POTS since contracting the flu in 2022, I have GI issues with early signs of celiac on my endoscopy, and I MTHFR heterozygous. Though, I'm not The MTHFR variant decreases the ability for the MTHFR enzyme to utilize riboflavin, and adding additional riboflavin can compensate for that. I swapped it out for a Folinic acid and hydro/Adeno multivitamin and that ALSO caused me anxiety. Do you think adeno and hydroxo forms of b12 would solve my problem? Get the Reddit app Scan this QR code to download the app now. If your attention perked up when you saw that today's blog is about overmethylation, I was started on the 15mg deplin (l-methyl folate) and it was too much for me, very activating! Increased my anxiety and insomnia. I am considering stopping I get anxiety and insomnia when I add b12 in the mix, but I just take the basic common form, I forgot what it’s called. azr lzmgzmu fue cosvgti vnhkpsqj zrasc atmcf cqvla pxlzp bgidut